These results confirm the detrimental functions of fundamentally stimulated FoxO1 throughout extreme liver insulin resistance in hyperglycemia and the insulin receptor monolayers of the insulin signaling branch phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt)-FoxO1 underlying the hepatic insulin-controlled glucose homeostasis [95]. The gene discussed is FOXO1; the disease is Insulin resistance.