FOXO1 and type 2 diabetes mellitus: Pyrrolidine dithiocarbamate (PDTC) can suppress blood sugar amount and boost insulin sensitization in diabetic rodents, and Ding and colleagues stated that therapy with PDTC greatly decreases oxidative stress and induces the apoptosis of β-cells in experimentally induced T2DM rats, along with increasing insulin production by downregulating acetylation with FoxO1 [143].