As phosphorylation of STAT3 leads to the activation of anti-inflammatory SOCS3 signaling, which in turn inhibits, for example, proinflammatory TNF-α, IL-10-induced SOCS3 mRNA expression in healthy control and VEO-IBD iPSC-derived macrophages was measured by qRT-PCR. This evidence concerns the gene IL10 and inflammatory bowel disease.