CD274 and neoplasm: The expression of PD-L1 on ICs appears to be of greater magnitude and of longer duration than on TCs and PD-L1 expression is IFNγ-dependent in TCs but only partially IFNγ-dependent in ICs [9,32], suggesting that the majority of PD-L1 in the immunosuppressive tumor microenvironment may be provided by ICs [32].