CD8A and neoplasm: In an analysis of tumors from patients with metastatic UC who had received atezolizumab [81], response to treatment was associated with a CD8+ T-cell phenotype and, to a greater extent, high TMB and lack of response were associated with TGFβ signaling in fibroblasts, which was found predominantly in tumors that showed exclusion of CD8+ T cells from tumor parenchyma.