PCK1 and steatosis: Cu excess in Atp7b-/- animals promotes decreased steatosis, hepatic AMP-activated protein kinase (AMPK) activation, and decreased gluconeogenesis and lipogenesis with associated decreased levels of phosphoenolpyruvate carboxykinase-1 (PEPCK1), pyruvate carboxylase (PCX), fructose-bisphosphatase-1 (FBP1), fatty-acid synthase (FASN), acetyl-CoA carboxylase (ACC1) and SREBP-1c transcription.