UV-light-inactivated herpes simplex virus-1 (UV-HSV-1) exerts cytolysis of AML cells via activation of leukemia-directed immune response and, synergistically with IL-15 and IL-2, induces cytolytic activity of stimulated NK cells, suggesting UV-HSV-1 as a therapeutic supplement to reinforce adoptive cell therapy [164]. This evidence concerns the gene IL15 and acute myeloid leukemia.