Incidence of adverse events and objective response to CTLA-4 blockade appears to be dose-dependent and response to treatment has been linked to histological subtypes of malignancies as a durable remission was noted in the enrolled extramedullary AML cases including three with leukemia cutis who also developed a mild GVHD [12,13]. The gene discussed is CTLA4; the disease is acute myeloid leukemia.