The engineered adenoviral vector, zA4, coated by TNF-apoptosis-inducing related-ligand (TRAIL) efficiently evokes cytotoxicity and significantly inhibits leukemia-cell proliferation, and additive ginsenoside (Rh2) enforces anti-tumorgenicity by inducing the expression of TRAIL-related receptors on leukemic blasts [163]. The gene discussed is TNFSF10; the disease is leukemia.