The time-delay between symptom onset and the start of production of IgM and IgG antibodies in response to infection (τM and τG, p = 0.84 and p = 0.79, Wilcoxon rank-sum test) as well as the baseline concentration of IgM and IgG antibodies (IM0 and IG0, p = 0.44 and p = 0.13, Wilcoxon rank-sum test) were not statistically different between two groups (Figure 2A). Here, CD40LG is linked to infection.