Metabolic disorders such as obesity and DM (diabesity) are known to be associated with low-grade chronic inflammation (metaflammation) and endothelial dysfunction, and were identified as risk factors for HF and HFH, also in post-infarct patients with elevated CRP [1,7,26,28,66,67]. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.