[131I]ICF01012 is a melanin-targeting compound that has already shown its efficiency by reducing tumor growth and enhancing survival in various syngeneic and xenograft pigmented melanoma models with wild-type or mutant BRAF [18,19,20,21], whereas injection of [131I] alone or of non-labeled ICF01012 in mice bearing B16 melanomas did not modify mice survival and tumor growth [21]. This evidence concerns the gene BRAF and melanoma.