PRAME and cancer: Although PRAME belongs to the category of cancer-testis antigen, it is aberrantly reexpressed in many types of cancers, including metastatic melanoma, head and neck carcinoma, renal cell cancer, multiple myeloma, non-small cell lung carcinomas, neuroblastoma, chronic myeloid leukemia, acute leukemia, uveal melanoma, several sarcoma subtypes, and in triple-negative breast cancers.