Beyond its involvement in DNA hypomethylation [10,15], one leading hypothesis for its antiapoptotic activity relies on its ability to repress, in a cancer-specific manner, the expression of the potent tumor suppressor TRAIL through the binding to RAR (retinoic acid receptor) and to EZH2 that epigenetically represses TRAIL gene expression [25,26]. Here, EZH2 is linked to cancer.