AKT1 and cancer: In several cancers models, such as prostate and breast cancer, Qu has been associated in mediating several angiogenesis pathways, including the Vascular Endothelial Growth Factor Receptor-2 mediated pathway of angiogenesis, repressing the downstream-regulatory target AkT expression; thus, restraining and restricting growth of the tumor [80,85].Lian Wang et al., through a mice model study, stated that Qu, as an angiogenesis inhibitor, reduces neovascularization growth, which is mediated via the inhibition of cyclooxygenase-2 (COX-2) [86].