Molecular processes of TRAIL resistance and reactivation of the apoptotic machinery by Qu in non-Hodgkin’s lymphoma (NHL) cell lines were determined by Jacquemin et al., where the role of Qu in mediating survivin and Mcl-1 downregulation restoring TRAIL-induced apoptosis in NHL B cells was assessed. The gene discussed is MCL1; the disease is non-Hodgkin lymphoma.