Deregulation of multiple molecular signaling pathways such as Wnt/β-catenin, Ras mitogen-activated protein kinase (Ras/Raf/MAPK), phosphatidylinositol 3-kinase (PI3K), AKT/mammalian target of rapamycin (mTOR), Janus kinase (Jak)-signal transducer activator of transcription factor (Stat) (JAK/STAT) and the Hippo signaling pathway are essential for HCC development and progression [11]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.