DTX1 and acute lymphoblastic leukemia: Accordingly, recent in vitro studies showed that Notch trafficking can be impaired through the disruption of zinc homeostasis resulting in the suppression of the Notch target gene Deltex E3 Ubiquitin Ligase 1 (DTX1) and consequently the NVS-ZP7-4 zinc transporter inhibitor (ZIP7) induced apoptosis in T-ALL, warranting further investigation [149].