Intra-peritoneal administration of a miR-148a-liposomal formulation in PTEN KO mice, before or after tumor development, decreased tumor size and incidence, tumor grade (hepatocellular and cholangiocellular adenomas were observed, instead of HCCs), and progenitor cell markers, while increasing hepato-specific markers (HNF4A, ALB and miR-122). The gene discussed is HNF4A; the disease is neoplasm.