Programmed cell death protein 1 (PD1), Programmed Death-Ligand 1 (PDL1), Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) are the most targeted ICPI in HCC proving to be more effective than Tyrosine Kinase Inhibitors (TKI), especially in combination regimens [9]. The gene discussed is CTLA4; the disease is hepatocellular carcinoma.