NSC or cancer cell fate is determined based on specific E2 factor transcription factor E2Fx TFs (x = 1, 2, 3, 4 and 6, i.e., E2F1, E2F2, E2F3, E2F4, E2F6 such as E2F6 in a complex with transcription factor dimerization partner 1 [TFDP1]) bound to the promoter within the IGR of the |-SRGAP2–FAM72-| master gene. Here, E2F6 is linked to cancer.