Interchangeable roles of E2Fx family members were revealed by a comprehensive ChIP analysis of E2F1 (e.g., E2F1-3a activators), E2F4 (e.g., E2F4-5 canonical repressors), and E2F6 (e.g., E2F6-8 atypical repressors) in normal and tumor cells [55], while loss of one E2F member could cause a function compensation by the other E2Fs to ensure cell cycle operation [58,59]. Here, E2F1 is linked to neoplasm.