To further test the relationship between IDH mutations and SOCS3, VEGFA, and TEK methylation, we grouped primary glioma and GBM cases in the TCGA-LGG/GBM dataset into cohorts with mutated (MT) and WT IDH1. These cases were aligned with decreasing β values of SOCS3 methylation, representing the percentage of DNA methylation ratio in each cohort. This evidence concerns the gene IDH1 and central nervous system cancer.