SOCS3 and the angiogenesis markers ANGPT1, ANGPT2, FLT1, PECAM1, TEK, TIE1, VEGFA, NRP1, and KDR were classified anatomically into structures of leading edge (LE), infiltrating tumor (IT), cellular tumor (CT), pseudopalisading cells around necrosis (PAN), and microvascular proliferation (MVP) from the histological Ivy Glioblastoma Atlas Project (Ivy-GAP) dataset (Figure 1A) [19]. This evidence concerns the gene TIE1 and neoplasm.