CD44v6 is a biomarker associated with colon cancer stemness and tumor progression [51,52], and hyaluronan-engaged CD44v3 induces the expression of stem cell markers, NANOG, SOX2, and OCT4, promoting tumor progression and chemoresistance of head and neck squamous cell carcinomas [18,53]. This evidence concerns the gene POU5F1 and head and neck squamous cell carcinoma.