Cleavage of CD44 has been observed in several types of tumors, and increases in response to stimulation with fragmented hyaluronan, activation of protein kinase C (PKC), and activation of RAS [45,46,47], and CD44 ICD has been shown to promote epithelial–mesenchymal transition and the stemness of tumor cells [34]. This evidence concerns the gene PRRT2 and neoplasm.