Besides the relevant role of the PD-1/PD-L1 axis in mediated immunosuppression in the TME, Dammeijer et al. showed that this pathway could also be activated in tumor-draining lymph node (TDLN), which are enriched in tumor-specific PD-1 T cells abolishing the current idea that only occurs at the tumor site. This evidence concerns the gene CD274 and neoplasm.