DNAH8 and Parkinson disease: As summarized in Figure 3C–E, we found that the forward rate constants of ATPase reaction were higher in PD patients (kf,ATPasePD = 0.16 ± 0.03 s−1, n = 11) than that in age-sex matched controls (kf,ATPaseCT = 0.13 ± 0.02 s−1, n = 11) with a statistically significant p value of 0.013 (Figure 3C); and the mean metabolic rate of ATP production via the ATPase reaction was slightly higher in PD than CT although it did not reach a statistical significance (CMRATPPD = 7.50 ± 1.61 μmol/g/min, CMRATPCT = 6.65 ± 1.23 μmol/g/min, n = 11, and p = 0.18, Figure 3D).