CDH1 and obesity due to melanocortin 4 receptor deficiency: Risk factors, such as family history, diet, alcohol consumption, smoking, obesity, Helicobacter pylori infection, E-cadherin gene (CDH1) alteration, and polymorphisms of interleukin (IL-17 and IL-10) genes, are associated with a high incidence of GC [2,3,4,5].