MTOR and gastric cancer: Further analysis of the underlying molecular mechanism of its anticancer effect demonstrated that compound 9 exhibits a growth inhibitory effect against AGS human GC cells by inducing G2/M cell cycle arrest and reactive oxygen species (ROS)- and caspase-mediated apoptosis through the downregulation of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway [14].