Initial investigations showed that inhibition of NFkB selectively in astrocytes did not increase motor function or survival in SOD1G93A ALS mice [84,85], while deletion of NFkB signaling in microglia extended the mouse lifespan by reducing the release of pro-inflammatory markers produced by M1 microglia [84]. This evidence concerns the gene NFKB1 and amyotrophic lateral sclerosis.