PNPLA3 has not only been associated with the development of liver cirrhosis and HCC [4,23,24], but has also shown a stronger association when compared with other risk alleles (e.g., SERPINA1, TM6SF2, MBOAT7 or GCKR) [9,25,26,27]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.