PNPLA3 and metabolic dysfunction-associated steatohepatitis: On the one hand, the rs738409 G-allele encoding the I148M variant of patatin-like phospholipase domain-containing protein 3 (PNPLA3) has been linked with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis in the general population [1,2].