Previously, a large meta-analysis combining data from GWASs on coronary artery disease showed that the common MC4R variant rs663129, which is in complete linkage with the rs17782313 variant (R2 = 1), showed only a moderately increased risk with an odds ratio of 1.06 (p = 3.2 × 10−8) for coronary artery disease [26]. This evidence concerns the gene MC4R and coronary artery disorder.