For instance, TGF-β1 deficient mice showed a reduced age-related myocardial fibrosis and higher cardiac compliance compared to wild-type mice [66], whereas mice with enhanced TGF-β1 expression showed a significant increase of fibroblasts concentration and, as a consequence, an increased myocardial fibrosis [67]. Here, TGFB1 is linked to Myocardial fibrosis.