In addition, Traub et al. determined that the strong phosphorylation of pro-oncogenic pathways containing c-Jun, ERK-1/2, and STAT3 in Capan1 cells were induced by exogenous IL-4 stimulation [90], while the specific molecular inhibitor of STAT3 phosphorylation LLL12 [91], showed inhibition of pancreatic cancer cell survival. This evidence concerns the gene IL4 and familial pancreatic carcinoma.