In addition, it was reported that bispecific ligand-directed toxins DTEGF13 (catalytic fragment of diphtheria toxin linked to human EGF and IL-13) had high efficacy and decreased toxicity in PANC-1 and MIAPaCa-2 cells and in a mouse model of human pancreatic cancer [117,118]. The gene discussed is IL13; the disease is familial pancreatic carcinoma.