Interestingly, 15 of 16 (94%) specimens resected from PDAC patients exhibiting high-level co-expression of IL-13 and IL-4R had lymph node metastases [93], which reveals that IL-13 in conjunction with IL-4R in the pancreatic cancer cells seems to facilitate lymph node metastasis. The gene discussed is IL13; the disease is familial pancreatic carcinoma.