IL4 and neoplasm: Mohammed et al. described that the transgenic expression of a molecule comprised of IL-4-receptor exodomain linked to IL-7-receptor endodomain in a chimeric antigen receptor–prostate stem cell antigen T cells inverted the inhibitory effects of IL-4 on T cell proliferation, and then reversed immunosuppressive TME, leading to the depression of tumor activity in vitro and in vivo [105].