IL4R and familial pancreatic carcinoma: Wu et al. reported that IL-4 alone or combined with IL-17A strongly induced the expression of dual oxidase 2 and its cognate maturation factor, leading to long-lasting H2O2 production and DNA damage in pancreatic cancer cells, while increased expression of dual oxidase 2 and IL-4R in clinical tumor tissues was conversely associated with overall patient survival [85].