Among them, it was found that AXP3009 could restore PDA cell proliferation and antiapoptosis signaling suppressed by genipin through tertiary alterations that affect GAPDH stability and abate its nuclear translocation, suggesting that in high levels of ROS, GAPDH could exert an antitumor effect on the nucleus [45]. The gene discussed is GAPDH; the disease is Patent ductus arteriosus.