Indeed, LDHA-deficient murine tumors displayed higher cytotoxic activity of NK cells compared to controls, and myeloid-derived suppressor cells (MDSCs) were decreased in tumors with lower suppressive effect, suggesting that LDHA activity could also impact the antitumor immune response through the higher paracrine signaling of tumor-derived lactate [80]. The gene discussed is LDHA; the disease is neoplasm.