KRAS and neoplasm: The recruitment of macrophages has been previously observed in KRAS-mutated PDA cells by chemokine secretion [11]; in addition, CCL18 secreted by protumoral M2 macrophages induced aerobic glycolysis in PDA cells, promoting tumor survival and, in turn, the increase in lactate facilitated the conversion of M0 macrophages to M2 macrophages [196,200].