SLC40A1 and dilated cardiomyopathy: The analysis of mice with cardiomyocyte-targeted ablation of the FPN coding gene has generated conflicting results: one study showed iron accumulation within cardiomyocytes and consequent heart dysfunction leading to fatal dilated cardiomyopathy despite an unaltered systemic iron level and downmodulation of TfR1-mediated iron uptake, thereby showing that FPN-dependent iron release is necessary to maintain cardiac iron homeostasis [48].