DHX33 interacts with the architectural protein UBF and indirectly regulates RNA polymerase I-mediated transcription and rRNA synthesis [100]; promotes the assembly of 80S ribosome at the late stage of mRNA translation initiation [101]; selectively regulates transcription of MMP9, MMP14 and PLAU genes involved in the regulation of cancer cell invasion and migration [102]; and participates in the innate immune response to double-stranded and bacterial RNA in the cell cytosol [103]. Here, DHX33 is linked to cancer.