Moreover, in AML (adult acute myeloid leukemia) cells, 50% of the genes downregulated by PRMT5 inhibition were partially rescued in expression upon inhibition of EZH2 activity, providing evidence of the critical role for PRC2-EZH2 in methylation and subsequent repression of these target genes [44]. This evidence concerns the gene EZH2 and acute myeloid leukemia.