We previously reported the clinical relevance of immune cells, including CD8+ T cells [30], regulatory T cells [31], and dendritic cells (DC) [32], as well as stromal cells such as fibroblasts [8], in the TME using the xCell algorithm, which allows us to estimate the fraction of 64 cells in the TME with the transcriptome of a bulk tumor. The gene discussed is CD8A; the disease is neoplasm.