MLXIPL and lung adenocarcinoma: Snail1, which mediates TGFβ1-induced EMT, was found to suppress the expression of the key lipogenic transcription regulators, carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein (SREBP), in A549 lung adenocarcinoma cells, leading to downregulation of the fatty acid synthase, FASN [80].