The results indicate that the positive regulation of this gene and its protein, which are key to promoting the progression of the cell cycle, is a oncogenic mechanism probably involved in the malignant transformation of melanocytic cells, justifying its frequent presentation by the number of oncogenic aberrations—gene amplification, mutations, polymorphisms, chromosomal translocations—and molecular pathways that conclude with the upregulation of CCND1/cyclin D1 in melanomas [22]; however, this upregulation, although frequent, was not different in the different types of cutaneous melanomas. This evidence concerns the gene CCND1 and melanoma.