Only one study has evaluated both the nuclear and cytoplasmic expression of cyclin D1 in melanomas, so it has not been possible to obtain data to meta-analyze; however, our research group has recently reported in oral squamous cell carcinoma [58], the association of cytoplasmic cyclin D1 overexpression with the development of actin-based protrusive structures—invadopodia and lamellipodia—in tumor cells, which functions are related with the acquisition of invasive advantages of malignant cells. This evidence concerns the gene CCND1 and neoplasm.