A significant correlation of both WNT5A and ROR2 (p < 0.001, Figure 4D) as well as another eight genes (p < 0.001, Figure S2) with LEP were observed in the ccRCC cohort, indicating the potential regulatory function of leptin in activating the PCP axis. The gene discussed is WNT5A; the disease is nonpapillary renal cell carcinoma.