The inflammatory response in non-type 2 asthma is dominated by type 1 and/or type 17 T-cell and many of these asthmatics suffer from comorbidities, including obesity, glucose dysregulation and hypertension as part of the metabolic syndrome, characterized by higher plasma levels of IL-6 [27]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.