These studies showed that treatment with high-volume hemofiltration (HVHF) at a dose of 6 L/hr of sepsis-induced ARF significantly reduced IL-6 levels (p = 0.025) and the overall organ failure assessment (SOFA) score was improved after one week, suggesting the important role of CRRT in patients who develop ARF, though further studies are needed. This evidence concerns the gene IL6 and acute kidney injury.