PTEN and tongue squamous cell carcinoma: It was also shown to have a biological importance in development of tongue squamous cell carcinoma by inhibiting cancer cell apoptosis [40] and regulation of the expression of multiple target genes important for cancer progression such as phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4) that regulate the radiosensitivity and sensitivity to cisplatin in OSCC [41].