BMP7 and aortic stenosis: As BMP7 signalling is dysregulated in mouse models of HF and in patients with aortic stenosis [15], and administration of recombinant BMP7 (rh-BMP7) protein had beneficial effects in the prevention of fibrosis in mouse models of HF [15,16], we investigated the anti-fibrotic effects of tilorone in human cardiac fibroblasts in vitro and in vivo using a mouse model of pathological cardiac remodelling due to pressure overload.