Genetic testing should also be considered for all patients with a diagnosis of gastric neoplasia and a family history compatible with Lynch syndrome, FAP, Peutz–Jeghers, Li–Fraumeni, juvenile polyposis, hereditary breast and ovarian cancer syndrome (germline mutations in BRCA1 or BRCA2). The gene discussed is BRCA2; the disease is Familial adenomatous polyposis.