In the current study, we present an overview and update of epigenetic changes described in the context of mastocytosis so far: (1) Histone modifications in neoplastic MC, (2) Epigenetic modifications of KIT, (3) Methylation status of apoptosis-associated and tumor suppressor genes in HMC-1 cells, (4) Somatic mutations in genes regulating epigenetic mechanisms, (5) TET2, (6) DNMT3A, (7) 5-methylcytosine (5-mC), 5-hydroxymethylcytosine (5-hmC) level, (8) microRNA, (9) MITF and microRNA. This evidence concerns the gene MITF and mastocytosis.