Though more studies are needed to build a clear relation between lysosomal Ca2+ and cancer development and to underpin the precise mechanisms underlying the role of lysosomal Ca2+ in different types of cancers, developing potent and specific compounds targeting TRPML1 [151,153] and TPC2 [61] could be a promising therapeutic strategy to treat some cancers. The gene discussed is TPCN2; the disease is cancer.