However, negative regulation of some target genes, such as MGMT and Cx43, may also elicit contrary effects and sensitize GBM to therapy (e.g., via inhibition of DNA repair (MGMT), inhibition of microtubule-dependent proliferation and invasion (Cx43), and enhancing radio- and chemo resistance (MGMT, Cx43)) [41,42,43,44]. This evidence concerns the gene GJA1 and glioblastoma.