ARHGEF11 and Dravet syndrome: They generated specific DS rats with SS-Arhgef11SHR, having the SHR allele substituted for the DS allele of Arhgef11 and showing reduced Arhgef11 expression, and demonstrated that SS-Arhgef11SHR significantly decreased proteinuria, fibrosis, and improved renal hemodynamics without impacting BP compared to the control DS rats [103].