A recent comprehensive analysis delineated the transcriptional regulatory network in a panel of neuroblastoma cell lines and demonstrated that the majority of the neuroblastoma cell lines (18/25) exhibit a noradrenergic identity characterized by enhanced regulatory circuits involving PHOX2A, PHOX2B, HAND2, GATA2, and GATA3 [27]. Here, HAND2 is linked to neuroblastoma.