Data mining of our previous human HCC transcriptome dataset [29,30] showed that the gene expression of CERS2, CERS4, CERS5, and CERS6 was significantly increased in HCC tumors compared with that in non-tumor adjacent tissues, while no obvious difference was observed in ASAH1 gene expression (Figure S3). The gene discussed is CERS6; the disease is hepatocellular carcinoma.