EZH2 and T-cell non-Hodgkin lymphoma: The importance of the oncogenic role of EZH2 independent of its methyltransferase activity was further underscored in natural killer/T-cell lymphoma in which ectopic expression of an EZH2 mutant form lacking methyltransferase activity was able to confer a growth advantage as well as to rescue growth inhibition as a result of endogenous EZH2 depletion [32].