Despite the biological complexity and adaptive nature of these lethal neoplasms, recent studies have identified some molecular and epigenetic markers, such as isocitrate dehydrogenase and O6-methylguanine-DNA-methyltransferase (MGMT) gene promoter, which are useful for predicting the prognosis and planning new targeted therapeutic options [12,13,14,15,16,17,18,19]. This evidence concerns the gene MGMT and neoplasm.