This is the case for several tumor suppressor genes, like CDKN2B (also known as p15), CDKN1C (p57), DLC1, and the JAK-STAT-negative regulator PTPN6, whose promoters become aberrantly hypermethylated, causing their expression to be downregulated in BCP-ALL [108,109,110,111,112]. This evidence concerns the gene CDKN2B and acute lymphoblastic leukemia.