Surveillance for cases of acute flaccid paralysis (AFP) in children and virologic testing is one of the four strategic pillars for eradication used by the Global Polio Eradication Initiative (GPEI); however, surveillance for AFP has low sensitivity for poliovirus infection, as paralysis occurs in <1% of poliovirus infections, which may limit the detection of poliovirus circulation in areas of low transmission [1,2,3]. The gene discussed is AFP; the disease is poliovirus infection.