HSP90AB1 and amyotrophic lateral sclerosis: Supporting our data, a recent study using proteomics and bioinformatics tools has reported activation of stress responses in gastrocnemius muscle of ALS-Tg mice, involving HSP90AB1, abnormalities in the endoplasmic reticulum (ER) protein folding machinery, and activation of the unfolded protein response (UPR) [61].