While Bet is not required for FV infection in vitro in most assays [193,194,195,196], it has been proposed to regulate viral latency [192,197,198], establishing infection and maintaining persistence [199], to be involved in resistance to viral superinfection [200], and Bet of bovine FV (BFV) was characterized as a negative regulator of BFV replication [201]. The gene discussed is DNER; the disease is infection.