IGF1R and neoplasm: Indeed, supernatant from IGF1R-downregulating HCC boosted migration of CD8+ T lymphocytes in a transwell-based chemotaxis assay compared to that from corresponding control cells, indicating that miR-29a acts as a tumor suppression gene and a potential target for improving immunosuppressive status in tumor microenvironment of HCC [71] and thereby may serve as a candidate to advance the efficacy of immunotherapy.