Identified as most frequently mutated housekeeping gene in HCC tissue, mutant ACTB 3′UTR acted to inhibit miR-29a by direct interaction, whereby miR-29a target gene MCL1 apoptosis regulator, BCL2 family member (MCL1) was up-regulated to bolster tumor progression [47]. The gene discussed is MCL1; the disease is hepatocellular carcinoma.