Downregulated Robo1 by lentivirus-based miR-29a overexpression is involved in the inactivation of PI3K/AKT/mTOR axis, leading to impeded HCC cell proliferation, migration, and invasion in vitro and alleviated HCC tumor growth and metastasis in vivo [58]. The gene discussed is MTOR; the disease is hepatocellular carcinoma.