It shows, that in obesity, the increase of adiponectin level in SF is not as pronounced as in serum, which might be connected with the fact that the main source of SF adiponectin in the knee joint is the IPFP, which does not grow with to the same extent compared to adipose tissue in the course of obesity. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.