Functional deletion of ICP34.5 attenuates viral pathogenicity and allows the virus to replicate selectively in tumors, while deletion of the ICP47 gene reduces virally mediated suppression of antigen presentation and increase the expression of the HSV US11 gene, which in turn, promotes virus growth in tumor cells without impairing tumor selectivity (Table 1). This evidence concerns the gene RPS14 and neoplasm.